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Year : 2018  |  Volume : 4  |  Issue : 4  |  Page : 157-165

Biological image analysis using deep learning-based methods: Literature review

1 School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, Liaoning Province, China
2 College of Environmental Science and Engineering, Tongji University, Shanghai, China
3 Faculty of Information Technology, University of Jyväskylä, Jyväskylä, Finland
4 Institute of Digital Medicine, Biomedical Engineering College, Third Military Medical University, Chongqing, China

Correspondence Address:
Fengyu Cong
Faculty of Electronic Information and Electrical Engineering, School of Biomedical Engineering, Dalian University of Technology, No. 2, Linggong Road, Dalian 116024, Liaoning Province
Sijie Lin
College of Environmental Science and Engineering, Tongji University, Shanghai 200092
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/digm.digm_16_18

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Automatic processing large amount of microscopic images is important for medical and biological studies. Deep learning has demonstrated better performance than traditional machine learning methods for processing massive quantities of images; therefore, it has attracted increasing attention from the research and industry fields. This paper summarizes the latest progress of deep learning methods in biological microscopic image processing, including image classification, object detection, and image segmentation. Compared to the traditional machine learning methods, deep neural networks achieved better accuracy without tedious feature selection procedure. Obstacles of the biological image analysis with deep learning methods include limited training set and imperfect image quality. Viable solutions to these obstacles are discussed at the end of the paper. With this survey, we hope to provide a reference for the researchers conducting biological microscopic image processing.

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